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By Lisa Jo Rudy, About.com

Updated: October 05, 2008

About.com Health's Disease and Condition content is reviewed by the Medical Review Board


An Alternative Perspective: How the MMR Is Thought to Cause Autism

Question:

As I understand it, the theory states that MMR and other live-virus vaccines may be negatively impacting certain children who are born with a compromised immune system. For these children, viruses and yeast growing in the gut lead to developmental problems in the brain, which present as autism spectrum disorders. Is this a correct synopsis of your theory, or am I off base?

Answer:

MMR and other live-virus vaccines negatively impact certain children with a vulnerable immune system. This immune weakness is likely to be genetic but can also be induced or made worse by environmental toxins. These children fail to clear viruses appropriately, and the viruses may remain in the gut and other body tissues. The immune system responds with a dysregulated production of cytokines, leading to an abnormal degree of inflammation. Initially the inflammation occurs in the gut but ultimately inflammation occurs in the brain. Neurological inflammation affects behavior, presenting as an autism spectrum disorder.

Question: Is there any theory as to why these particular children would have immune issues?

Answer:

Dr. Bryan Jepson calls it the 'multiple hit' hypothesis.Imagine an embryo with genetically susceptible chromosomes that prevent it from detoxifying normally. The embryo is exposed to toxins like mercury from maternal fish consumption and maternal amalgams, mercury from the mother’s flu vaccine and possibly her rhogam shot, antibiotics given to the mother, and other placental toxins. Combined with toxins the baby is exposed to after birth, these exposures start to weaken the immune system of a susceptible child, creating early inflammation. The baby accumulates some of the toxins that they can’t excrete. The immune system and the detoxification system really take months before they start to become mature. As the child gets older, he or she receives many more immunizations. Food antigens are introduced, like casein from cow’s milk. The child gets repeated viral infections. They develop chronic ear infections and are given multiple courses of antibiotics. The antibiotics damage their gut even more, allowing more toxins to enter their system. The child develops a leaky gut, tissue damage gets worse, the immune system grows weaker, and autoimmune reactions start. Then a lot of children experience a catastrophic event. Either in the form of a significant illness or a live virus vaccine. The immune system is overwhelmed and the child rapidly goes downhill. Some parents report a gradual deterioration, but many children seem to develop autism after a particular event. They go into the hospital or they get an MMR shot and they’re never the same again. Autism is the end result of this developing series of reactions.

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